Coronavirus replication and reverse genetics - download pdf or read online

By Luis Enjuanes

ISBN-10: 128030491X

ISBN-13: 9781280304910

ISBN-10: 3540214941

ISBN-13: 9783540214946

ISBN-10: 3540267654

ISBN-13: 9783540267652

Human coronaviruses triggered the SARS epidemic that contaminated greater than 8000 humans, killing approximately ten percentage of them in 32 international locations. This ebook presents crucial details on those viruses and the advance of vaccines to manage coronavirus infections.

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Additional info for Coronavirus replication and reverse genetics

Example text

If these contained an antileader sequence at their 30 end and a poly U at their 50 end, they could be directly transcribed into the subgenomic mRNAs. Thus the presence of subgenomic minus strands suggested a replication strategy that would be common to coronaviruses (and arteriviruses) and unique among the singlestranded RNA animal viruses. We suggested and favor the hypothesis that subgenomic minus strands are produced by discontinuous transcription directly from genome plus strands and are the only templates for subgenomic mRNAs.

J Gen Virol 81:853–879 CTMI (2005) 287:31--55  Springer-Verlag 2005 Coronavirus Transcription: A Perspective S. G. Sawicki ()) · D. L. edu 1 Introduction . . . . . . . . . . . . . . . . . 32 2 Discontinuous Transcription by Coronaviruses . . . . . . . 35 3 Kinetics of Plus- and Minus-Strand RNA Synthesis and Sensitivity to Translational Inhibition . . . . . . . . 41 4 The Kinetics of Synthesis of the Subgenomic Minus Strands . . . 42 5 Subgenomic MHV RIs Exist in Infected Cells and Are Transcriptionally Active in mRNA 2–7 Synthesis .

142:629–633 Chang RY, Brian DA (1996) Cis requirement for N-specific protein sequence in bovine coronavirus defective interfering RNA replication. J Virol 70:2201–2207 Chang RY, Hofmann MA, Sethna PB, Brian BA (1994) A cis-acting function for the coronavirus leader in defective interfering RNA replication. J Virol 68:8223–8231 Chang RY, Krishnan R, Brian DA (1996) The UCUAAAC promoter motif is not required for high-frequency leader recombination in bovine coronavirus defective interfering RNA. J Virol 70:2720–2729 Chouljenko VN, Lin XQ, Storz J, Kousoulas KG, Gorbalenya AE (2001) Comparison of genomic and predicted amino acid sequences of respiratory and enteric bovine coronaviruses isolated from the same animal with fatal shipping pneumonia.

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Coronavirus replication and reverse genetics by Luis Enjuanes


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