Circulating microRNAs in Disease Diagnostics and their by Peter Igaz PDF

By Peter Igaz

ISBN-10: 3034809530

ISBN-13: 9783034809535

MicroRNAs because the endogenous mediators of RNA interference have skilled an exceptional profession lately, highlighting their pathogenic, diagnostic and strength healing relevance. Beside tissue microRNAs, also they are present in physique fluids, such a lot particularly in blood. major alterations of circulating microRNA degrees were present in quite a few illnesses, making them applicants for minimally invasive markers of illness, for instance tumor malignancy. The publication focuses on the capability diagnostic applicability of circulating microRNAs in quite a few illnesses and their strength organic value.

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One of these proteins was found to be heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1). Once modified post-translationally by small ubiquitinlike modifier (SUMO) proteins, the sumoylated hnRNPA2B1 bound a subset of miRNAs bearing a GGAG motif in their 30 -region, leading to their sorting to EVs. Other similar motifs were found too and named collectively “EXOmotifs”, motifs that are found overrepresented in EV-associated miRNAs (Villarroya-Beltri et al. 2013). Interestingly, miRNAs bearing certain other nucleotide signatures were preferentially retained in cells (Villarroya-Beltri et al.

G. the miR-122 inhibitor LNA-modified antimiR miravirsen is already in clinical phase 2 and can be the first miRNA therapeutics in the treatment of HCV infection (Janssen et al. 2013; van Rooij and Kauppinen 2014; Wahid et al. 2014). Other approaches include the miRNA sponges where multiple miRNAs can be affected by a single construct under a strong promoter and gene-specific miRNA masking targeting the miRNAbinding site in the target messenger mRNA (McDermott et al. 2011). The other opportunity is restoring the activity of underexpressed miRNA by miR mimics.

3 miRNA Exported in Microvesicles, Exosomes and other Membrane Encapsulated Vesicles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Biogenesis of Microvesicles and Exosomes . . . . . . . . . . . . . . . . . . . . 2 Mechanism for miRNA Loading and Secretion in EVs . . . . . . . . . . . . . 3 EV Uptake and Biological Effects of miRNAs in Recipient Cells .

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Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance by Peter Igaz


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