Get Cilia and Mucus: From Development to Respiratory Defense PDF

By Matthias Salathe

ISBN-10: 0585408300

ISBN-13: 9780585408309

ISBN-10: 082470441X

ISBN-13: 9780824704414

This ebook info advances in examine relating to cilia, mucus, and mucociliary clearance, reading adjustments in mucus expression and goblet phone metaplasia, and assessing the power of the mucociliary procedure to answer abnormalities. acknowledges that cilia and dynein hands play pivotal roles in constructing mammalian embryos!Examines the position of genetics in basic and irregular ciliary function!Discussing clinical basics, present diagnostic ideas, and clinically validated remedies, Cilia and Mucus analyzes the legislation of ciliary waves on the mobile point considers irregularities of higher and decrease airlines and cilia in structures of the physique explores capability modulators of airway mucin secretion proposes a unique treatment for airway hypersecretion a result of epidermal development issue cascade clarifies gamma digital camera imaging to degree mucociliary clearance describes the influence of purinergic receptors and dry powder mannitol on airway passages and extra! With contributions from over a hundred overseas researchers and clinicians, and containing over 1300 references, drawings, pictures, tables, and equations, Cilia and Mucus is a distinct single-source reference for pulmonologists, physiologists, immunologists, allergists, otolaryngologists, pediatricians, microbiologists, simple scientists, and graduate and clinical college scholars in those disciplines.

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Additional info for Cilia and Mucus: From Development to Respiratory Defense

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Localization of dynein in sea urchin eggs during cleavage. Develop Growth Differ 18:391–397, 1976. 34. CM Pfarr, M Coue, PM Grissom, TS Hays, ME Porter, JR McIntosh. Cytoplasmic dynein is localized to kinetochores during mitosis. Nature 345:263–265, 1990. 35. ER Steuer, L Wordeman, TA Schroer, MP Sheetz. Localization of cytoplasmic dynein to mitotic spindles and kinetochores. Nature 345:266–268, 1990. 36. EA Vaisberg, MP Koonce, JR McIntosh. Cytoplasmic dynein plays a role in mammalian mitotic spindle formation.

Elegant biochemical studies performed in Chlamydomonas have demonstrated that the basic subunit of IFT raft particles is a 16S multiprotein complex consisting of a minimum of 15 polypeptides (8,21,22). Two of these polypeptides share sequence homology with the OSM-1 and OSM-6 proteins that are required for sensory cilia function in the nematode Caenorhabditis elegans (8,22). Interestingly, C. elegans have no motile cilia, but possess only sensory cilia that comprise the terminal endings of a subset of neurons (60 out of a total of 302 neurons) in the adult worm (3,23).

Using this assay we hope to completely dissect the active-transport pathways required for building a ciliated sensory neuron. EXPERIMENTAL DESIGN To visualize the movement of microtubule motors and putative cargo molecules in living C. elegans cells, heritable lines of transgenic worms are isolated that express these proteins labeled with the green fluorescence protein (GFP) (26). The in vivo transport of these fusion proteins is then monitored using time-lapse fluorescence microscopy (Fig. 1A).

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Cilia and Mucus: From Development to Respiratory Defense by Matthias Salathe

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