Download PDF by : Ciba Foundation Symposium 35 - Biochemistry and Pharmacology

ISBN-10: 0470720174

ISBN-13: 9780470720172

ISBN-10: 9021940396

ISBN-13: 9789021940397

Content:
Chapter 1 advent (pages 1–4): G. V. R. Born
Chapter 2 universal Pathways of Membrane Reactivity after Stimulation of Platelets through assorted brokers (pages 5–21): Ernst F. Luscher and P. Massini
Chapter three Binding of Adenosine Diphosphate by way of Human Platelet Membrane (pages 23–46): Ralph L. Nachman
Chapter four Enzyme actions at the Platelet floor when it comes to the motion of Adenosine Diphosphate (pages 47–75): J. Fraser Mustard, M. A. Packham, D. W. Perry, M. A. Guccione and R. L. Kinlough?Rathbone
Chapter five Stimulus?Response Coupling within the Thrombin?Platelet interplay (pages 77–100): Thomas C. Detwiler, Bernice M. Martin and Richard D. Feinman
Chapter 6 The interplay of Platelet Actin, Myosin and Myosin gentle Chain Kinase (pages 101–119): Robert S. Adelstein, Mary Anne Conti, James L. Daniel and William Anderson
Chapter 7 Roles of Cyclic Nucleotides in Platelet functionality (pages 121–151): Richard J. Haslam
Chapter eight preliminary Biochemical Responses of Platelets to Stimulation (pages 153–173): D. C. B. Mills
Chapter nine Biochemistry of the Platelet liberate response (pages 175–205): Holm Holmsen
Chapter 10 Prostaglandins and Precursors in Platelet functionality (pages 207–224): J. Bryan Smith, Carol M. Ingerman and Melvin J. Silver
Chapter eleven importance of Glucose and Glycogen Metabolism for Platelet functionality (pages 225–238): W. Schneider and A. R. L. Gear
Chapter 12 Elemental Composition of Platelet Dense our bodies (pages 239–259): R. J. Skaer
Chapter thirteen The Organelles Storing 5?Hydroxytryptamine in Blood Platelets (pages 261–286): A. Pletscher and M. Da Prada
Chapter 14 5?Hydroxytryptamine Receptors of Platelets (pages 287–307): G. V. R. Born and F. Michal
Chapter 15 Interactions among 5?Hydroxytryptamine and Platelet Lipid Fractions (pages 309–342): Aaron J. Marcus, Lenore B. Safier and Harris L. Ullman

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Additional info for Ciba Foundation Symposium 35 - Biochemistry and Pharmacology of Platelets

Example text

Radioactivity was measured in the platelet-free plasma and in the platelet pellet. The uptake was calculated as the volume occupied by the radioactive compound relative to its concentration in plasma. of ADP radioactivity and that very little uptake occurred using other labelled nucleoside diphosphates (GDP, IDP and UDP). Earlier work by Professor Born (1965) showed that the continuing uptake of ADP radioactivity represented the uptake of ADP metabolites, principally adenosine. Incubation at 18 "C, 27 "C and 37 "C resulted in significant differences in the slope of uptake of radioactivity; however, the three uptake curves extrapolated to a common value which we took as an indication of ADP binding.

Koch (1967) using the Dupont Luminescence biometer reagent kit (E. I. ). 51Cr in the supernatant solutions or in samples of the platelet suspensions was counted in a well-type crystal scintillation counter. RESULTS The addition of [14C]ADP to a suspension of washed rabbit platelets led to the formation of [14C]ATP (Table 1). At equirnolar concentrations, much less [14C]GDP and [14C]CDPwere converted to their triphosphates than was [14C]ADP to its triphosphate. Also shown in this table is the effect of adding ATP to the suspending medium.

In order to correlate the binding of the [14C]ADP by the membrane vesicles with physiologically induced platelet aggregation, we studied the relative inhibitory effects of various agents known to interfere with ADP-induced platelet aggregation. For these studies varying amounts of non-radioactive agents known to influence platelet function were preincubated with the membrane vesicle suspension, after which [14C]ADP was added (Fig. 3). ADP and 2-chloroadenosine were the most potent inhibitors of membrane [14C]ADP binding.

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Ciba Foundation Symposium 35 - Biochemistry and Pharmacology of Platelets


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