Download PDF by N. B. Myant: Cholesterol Metabolism, Ldl, and the Ldl Receptor

By N. B. Myant

ISBN-10: 0125123000

ISBN-13: 9780125123006

ISBN-10: 0323148875

ISBN-13: 9780323148870

Ldl cholesterol Metabolism, LDL, and the LDL Receptor

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Additional info for Cholesterol Metabolism, Ldl, and the Ldl Receptor

Sample text

Fro mOsborn ee ta/. , 1985 ,an dGi le ta/. ,1988 ,wit hth epermissio no fth eauthors. Not etha tth enumberin go fnucleotide si nthi sfigur ediffer sfro mtha ti nFigs . 3. Th esequence smarke dA- Pwer esubjecte dt osubstitutio nmutagenesi san dth emutan tpromoter swer eteste dfo r 46 3. H M G - C o A Reductas e shortsequenc ea tth e 3 'en do f FP 2 (Fig . 13 ) wa s replace db ya rando mse ­ quence, transcriptionwa s increased. O nth e othe rhand, ''scrambling"o f FP 4 o r ofa regio no f FP 6 containing th e atypica l TAT A bo x almos tabolishe dtranscrip­ tion.

The y als o showedtha twhe nmaxima l dose so f LD Lar e adde dt oa cultur e mediu mi n whichcell s ar e growin gi nth e absenc eo f lipoprotein , enzym e activit y decline s witha half-lif e (3. 0 hours ) simila rt o tha tobserve dafte radditio no f cyclohexi mide t o th e mediu m(2. 9 hours) . The y conclude dtha tLD Lsuppresse s reductas e activityi nfibroblastsi nculture b y repressiono f enzym e synthesi s rathe rtha nb y inactivating preexistin g enzym e molecule s o rincreasin g thei rrat eo f degrada tion.

0 042 pRedCA T- 9 5. (Fro mOsborn ee ta/. ,1985 ,wit hth epermissio no fth eauthors. Structur 7 81 pRed CAT- 21 pRed CAT- 12 8 61 0 75 pRed CAT- 310 R e l a t i v e Percen Promoter Suppressio Plasmid A c t i v i t yb y Sterol s 44 3. H M G - C o A Reductas e Since plasmi dpSVO-CATha s n o eukaryotic promote rsequences , expressio n of CA Ti ntransfectedcell s provide da ninde xo f promote ractivit yi nth e reduc tase-gene sequence s presen ti nth e constructs . Th e result so f thes e experiment s showedtha tal l th e sequence s require dfo rth e promotio nan dsterol-dependen t repressiono f transcriptionar e containe dwithi nth e 22 7 b pupstrea mfro mth e most 5 'o f th e multipl e initiatio nsite sfo rtranscriptioni nth e reductas e gene .

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Cholesterol Metabolism, Ldl, and the Ldl Receptor by N. B. Myant

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