Natanya Civjan's Chemical Biology: Approaches to Drug Discovery and PDF

By Natanya Civjan

ISBN-10: 1118101189

ISBN-13: 9781118101186

An authoritative examine the applying of chemical biology in drug discovery and development

Based at the award-winning Wiley Encyclopedia of Chemical Biology released in 2008, this publication explores the function of chemical biology in drug discovery and improvement. the 1st a part of the ebook reports key ideas and strategies utilized in the layout and assessment of drug applicants. the second one half elucidates organic mechanisms of sure ailments, illuminating ways to enquire and aim those diseases.

Comprising rigorously chosen reprints from the Encyclopedia in addition to new contributions from best students within the box, this e-book offers researchers in academia and with very important info to assist within the improvement of novel brokers to regard disorder. Self-contained articles hide a number of crucial subject matters, including:

  • The layout, improvement, and optimization of drug candidates
  • The pharmacokinetics and homes of drugs
  • Drug shipping and delivery
  • Natural items and normal product types as pharmaceuticals
  • Biological mechanisms underlying overall healthiness and disease
  • Treatment concepts for more than a few illnesses, from HIV to schizophrenia

Chemical Biology is a top-notch consultant and reference for a person operating within the parts of drug discovery and improvement, together with researchers in chemical biology and different fields equivalent to biochemistry, drugs, and pharmaceutical sciences

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Additional resources for Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease

Example text

Eur. J. Pharm. Sci. 2002;17:51–61. 46. Cecchelli R, Berezowski V, Lundquist S, Culot M, Renftel M, Dehouck MP, Fenart L. Modelling of the blood-brain barrier in drug discovery and development. Nat. Rev. Drug Discov. 2007;6:650–661. 47. Adenot M, Lahana R. Blood-brain barrier permeation models: Discriminating between potential CNS and non-CNS drugs including P-glycoprotein substrates. J. Chem. Inf. Comput. Sci. 2004;44:239–248. 48. Garg P, Verma J. In silico prediction of blood brain barrier permeability: an artificial neural network model.

61. Liu D, Xu Y, Feng Y, Liu H, Shen X, Chen K, Ma J, Jiang H. Inhibitor discovery targeting the intermediate structure of beta-amyloid peptide on the conformational transition pathway: implications in the aggregation mechanism of beta-amyloid peptide. Biochemistry 2006;45:10963–10972. 62. Kopec KK, Bozyczko-Coyne D, Williams M. Target identification and validation in drug discovery: the role of proteomics. Biochem. Pharmacol. 2005;69:1133–1139. 63. Stockwell BR. Exploring biology with small organic molecules.

Econ. 2003;22:151–185. 2. Jorgensen WL. The many roles of computation in drug discovery. Science 2004;303:1813–1818. 36 COMPUTATIONAL APPROACHES TO DRUG DISCOVERY AND DEVELOPMENT 3. Drews J. Drug discovery: a historical perspective. Science 2000;287:1960–1964. 4. Leader B, Baca QJ, Golan DE. Protein therapeutics: a summary and pharmacological classification. Nat. Rev. Drug Discov. 2008;7:21–39. 5. Huang CM, Elmets CA, Tang DC, Li F, Yusuf N. Proteomics reveals that proteins expressed during the early stage of Bacillus anthracis infection are potential targets for the development of vaccines and drugs.

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Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease by Natanya Civjan


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