Download e-book for iPad: Cellular Regulators Part A: Calcium- and Calmodulin-Binding by Anthony R. Means, P. Michael Conn (Eds.)

By Anthony R. Means, P. Michael Conn (Eds.)

ISBN-10: 0121820394

ISBN-13: 9780121820398

The significantly acclaimed laboratory normal, Methods in Enzymology, is likely one of the so much hugely revered courses within the box of biochemistry. due to the fact that 1955, every one quantity has been eagerly awaited, often consulted, and praised through researchers and reviewers alike. The sequence includes a lot fabric nonetheless proper this day - really a necessary ebook for researchers in all fields of lifestyles sciences

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Extra info for Cellular Regulators Part A: Calcium- and Calmodulin-Binding Proteins

Example text

Y. ), Vol. 4, p. 1. Academic Press, New York, 1983. 2 A. R. Means and J. R. Dedman, Nature (London) 285, 73 (1980). 3 p. B. Moore and J. R. Dedman, J. Biol. Chem. 257, 9663 (1982). METHODS IN ENZYMOLOGY, VOL. 139 Copyright © 1987 by Academic Press, Inc. All rights of reproduction in any form reserved. 20 ISOLATION/CHARACTERIZATION OF Ca-BINDING PROTEINS [2] subunit of the complex, troponin-C, binds calcium and activates muscle contraction. A second calcium-binding protein, calmodulin, forms an integral regulatory unit of a number of enzyme systems.

6 A. S. Manalan and C. B. Klee, J. Biol. Chem. 259, 2047 (1984). 7 C. E. Cmtz, L. G. Dowling, J. J. Sando, C. Villar-Palasi, J. Whipple, and W. J. Zaks, J. Biol. Chem. 258, 14664 (1983). 8 T. C. Sudhof, M. Ebbeke, J. H. Walker, U. Fritsche, and C. Boustead, Biochemistry 23, 1103 (1984). 9 R. J. Owens and M. J. Crumpton, Biochem. J. 219, 309 (1984). :0 j. H. Walker, J. Olrochi, and T. C. Sudhof, J. Neurochem. 41, 139 (1983). 05% NaN3 Frozen tissue (100 g) was crushed, mixed with 500 ml buffer A and homogenized in a Waring blender (3 x, 10 sec), with 5 min cooling on ice between each burst.

3 Purification is from 1000 g of bovine liver. b Calregulin is determined by the radioimmunoassay as described in the text. c Protein is determined according to M. M. Bradford [Anal. Biochem. 72, 660 (1976)] using bovine serum albumin as a standard. 89). calregulin displays two protein bands, the major of which has an Mr of 63,000 and the other an Mr 61,000. Previous studies 3,6 suggested that the band doublet was not due to the presence of contaminant but was instead due to the presence of two closely related proteins.

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Cellular Regulators Part A: Calcium- and Calmodulin-Binding Proteins by Anthony R. Means, P. Michael Conn (Eds.)


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