Catalytic Cascade Reactions - download pdf or read online
By Peng-Fei Xu, Wei Wang
ISBN-10: 1118016025
ISBN-13: 9781118016022
Demonstrates the benefits of catalytic cascade reactions for synthesizing common items and pharmaceuticals
Riding the wave of eco-friendly chemistry, catalytic cascade reactions became probably the most lively examine components in natural synthesis. in the course of a cascade response, only one response solvent, one workup process, and one purification step are wanted, hence considerably expanding man made efficiency.
Featuring contributions from a global staff of pioneers within the box, Catalytic Cascade Reactions demonstrates the flexibility and alertness of those reactions for synthesizing invaluable compounds. The publication examines either organocatalysis and transition-metal catalysis reactions, bringing readers brand new with the newest discoveries and actions in all significant parts of catalytic cascade response research.
Catalytic Cascade Reactions begins with 3 chapters devoted to organocatalytic cascade reactions, exploring amines, Brønsted acids, and the applying of organocatalytic cascade reactions in traditional product synthesis and drug discovery. subsequent, the booklet covers:
- Gold-catalyzed cascade reactions
- Cascade reactions catalyzed by way of ruthenium, iron, iridium, rhodium, and copper
- Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes
- Application of transition-metal catalyzed cascade reactions in ordinary product synthesis and drug discovery
- Engineering mono- and multifunctional nanocatalysts for cascade reactions
- Multiple-catalyst-promoted cascade reactions
All chapters are completely referenced, supplying easy accessibility to special unique study findings and experiences in order that readers can discover person themes in larger depth.
Drawing jointly and interpreting released findings scattered around the literature, this publication presents a unmarried resource that encapsulates our present figuring out of catalytic cascade strategies. furthermore, it units the degree for the improvement of latest catalytic cascade reactions and their functions.
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Additional resources for Catalytic Cascade Reactions
Example text
49 Cascade reaction of enals with malononitrile. 50 Dipolar [3 + 2] cycloadditions between nitrones and enals. 50) [84]. Improved diastereoselectivity was achieved when a triflate salt of diphenyl-S-prolinol and trimethylsilyl triflate was used to catalyze this reaction [85]. Highly chemo- and enantioselective organocatalytic three-component reaction of enals with in situ–generated nitrones from N-arylhydroxylamines and aldehydes was also reported [86]. Inspired by the MacMillan group’s LUMO-lowering strategy in cycloaddition reactions, Vicario et al.
1,4-Addition then occurred with the tautomeric structure of 1,2-cyclohexadione, resulting in the Michael adduct 147b, an activated enamine that subsequently underwent an intramolecular aldol reaction. 56 Catalytic cycle proposed for cascade Michael–aldol reactions with 1,2-cyclohexadione. A thia-Michael/aldol cascade [92] of α,β-unsaturated aldehydes with 3-mercapto α-carbonyl esters or 1,4-dithiane-2,5-diol and aza-Michael/aldol reactions of α,βunsaturated aldehydes with indole-2-carbaldehydes or pyrroles [93] was also developed.
2 Iminium-Activated Epoxidations Similar to ylide 153 and bromomalonates 157, it was proposed that hydrogen peroxide could also be used as an amphiphilic reactant for [2 + 1] reactions of α,β-unsaturated aldehydes to furnish epoxidation products. 63) [106]. The reactions take place under mild conditions in good to high yields and enantio- and diastereoselectivities. 63 Organocatalytic epoxidation of enals with hydrogen peroxide. 64). Formation of the epoxide then takes place by attack of the nucleophilic enamine carbon atom on the electrophilic peroxygen atom.
Catalytic Cascade Reactions by Peng-Fei Xu, Wei Wang
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