Download e-book for iPad: Cardiac Glycosides 1785–1985: Biochemistry — Pharmacology — by Prof. Dr. J. C. Skou (auth.), Prof. Dr. Erland Erdmann,

By Prof. Dr. J. C. Skou (auth.), Prof. Dr. Erland Erdmann, Prof. Dr. K. Greef, Prof. Dr. J. C. Skou (eds.)

ISBN-10: 3662112922

ISBN-13: 9783662112922

ISBN-10: 3662112949

ISBN-13: 9783662112946

The bicentenary of William Withering's now well-known scientific record entitled "An Account of the Foxglove and a few of its clinical makes use of" has given us the get together to investigate the state-of-the-art. Cardiac glycosides in 1985 are thought of tobe the foundation for clinical therapy of myocardial failure, including diuretics and vasodilators within the extra serious instances. however, the talk as to their distinct position within the therapy of middle failure with sinus rhythm hasn't ever ceased. even supposing cardiac glycosides are of unquestionable price in tachycardia as a result of atrial traumatic inflammation or atrial flutter, the persistent use of those medicines in sinus rhythm isn't really commonly authorised. the advance of tolerance has been mentioned. it truly is of curiosity that Withering hirnself wrote: "-let it (foxglove) be persevered till it both acts at the kidneys, the tummy, the heartbeat, or the bowels; Iet or not it's stopped upon the 1st visual appeal of any of those results, and that i will continue that the sufferer won't be afflicted by its exhibition, nor the practitioner be upset in any moderate expectation. " In West Germany on my own, greater than 3 million sufferers (about five% of the whole inhabitants) are regularly taking cardiac glycosides. those medicinal drugs are the main prescribed medicaments in lots of nations. therefore, we thought of it important and essential to evaluation in a serious manner latest wisdom concerning the foxglove; to document new findings and to guage outdated Statements.

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Additional resources for Cardiac Glycosides 1785–1985: Biochemistry — Pharmacology — Clinical Relevance

Example text

Nucleotide binding in the presence of K+ and ouabain binding, to Na,K-ATPase isolated from grey matter of the brain are incompatible with the existence of one homogeneaus population of receptors (1, 2, 11). Hansen (2) proposed that two (or more) populations of ox brain Na,K-ATPase with different affinities for ouabain could explain curvilinear Scatchard plots, although apparently a conversion to one uniformpopulationwas seen in the presence ofK+. The principal interpretations of curvilinear Scatchard-type plots of ouabain binding data were recently reviewed (4).

In the 19th century all known indications of external and internal uses remained valuable. In addition to wound healing, phthisis and consumption, there were scrofulosis, acute fevers, which were considered until the era of bacteriology as special clinical units, such as nerve fever, intermittent fever, so-called inflammations such as pneumonia, and also asthma, rheumatism, goiter and even mental diseases. Therefore for the medical historian it is not a peculiar surprise that the mentally ill German poet Friedrich Hölderlin ( 1770- 1843) was treated in the clinic of the University of Tübingen immediately after his admission on the 16th September 1806 with 6 grains of belladonna leaves and 2 grains of digitalis leaves dissolved in 2 ounces of aniseed-camomile water, as documented in the hospital's formulary.

2 represent the binding isotherms in a Scatchard-type plot. Obviously, the binding data are incompatible with a model assuming a simple bimolecular reaction between a homogeneaus population of receptors and purified CH)ouabain. Provided equilibrium exists between enzyme and the ligands ( e. g. 0 - ~· 75 ~ ~ ~ 111 ; ~ ~ 25 0 .............. 0 0 ~ 50 () () • ............. 5 mg pyrithiamin·ml- 1 during preincub. Fig. 1. Effect of pyrithiamin treatment of pig kidney Na,K-ATPase (upper curve) and ox brain Na,KATPase (lower curves) on the (Na++K+)-activated ATPase activity (0) and on the K+-activated pNPPase activity ( e).

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Cardiac Glycosides 1785–1985: Biochemistry — Pharmacology — Clinical Relevance by Prof. Dr. J. C. Skou (auth.), Prof. Dr. Erland Erdmann, Prof. Dr. K. Greef, Prof. Dr. J. C. Skou (eds.)


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