By Saul Suster MD, Cesar A. Moran MD
Biopsy Interpretation of the Lung aids pathologists in appropriately comparing illness tactics. It comprises specific chapters on interstitial lung ailment, lung melanoma, and neuroendocrine tumors. equipped by way of conventional illness teams, Biopsy Interpretation of the Lung offers a pretty good method of formulating surgical and scientific judgements.
This textual content is aimed at surgical pathologists, pathology citizens, pathology fellows, pulmonologists, pulmonology fellows, and thoracic surgeons, and contains the newest info at the most sensible use of immunohistochemical markers, specific stains, and molecular assays to assist in additional actual and cost effective diagnoses.
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Additional resources for Biopsy Interpretation of the Lung
34 polymyositis and dermatomyositis. Pulmonary involvement in polymyositis (PM) and dermatomyositis (DM) occurs with much less frequency than in other systemic diseases and usually manifests late in the course of the process. 17 The most common manifestation of PM/DM in the lungs is an interstitial pneumonitis with a pattern very similar to NSIP. 20 Interstitial fibrosis in PSS. This pattern of fibrosis is nonspecific and can be observed in various other disorders. Clinical correlation is required to establish the cause of the sclerosing process.
We recommend routinely ordering acid-fast and silver stains. 7 The histopathologic findings in chronic berylliosis are essentially indistinguishable from those of sarcoidosis and are characterized by multiple nonnecrotizing epithelioid granulomas with giant cells associated with variable degrees of fibrosis. In advanced stages, the granulomas may coalesce to form large, centrally hyalinized masses that can resemble old lesions of histoplasmosis. There is also an acute form of the disease characterized by a chemical pneumonitis with diffuse alveolar damage that develops rapidly following short-term, massive exposure to soluble beryllium salts.
Interstitial fibrosis may be associated with various metaplastic processes, including bronchiolar metaplasia and squamous metaplasia. 17). 15 Response to chronic inflammation characterized by bronchiolitis obliterans showing constrictive pattern of fibrosis and inflammation around the lumen of a small bronchiole. 16 Interstitial fibrosis resulting from chronic lung injury. Notice thickening of alveolar walls by interstitial collagen deposition. 17 Bronchiolar metaplasia (“lambertosis”) in chronic lung injury characterized by replacement of the alveolar lining by columnar, ciliated bronchiolar epithelium.
Biopsy Interpretation of the Lung by Saul Suster MD, Cesar A. Moran MD