Get Biochemistry and Biology of Coronaviruses PDF

By Lawrence S. Sturman (auth.), V. ter Meulen, S. Siddell, H. Wege (eds.)

ISBN-10: 1475704569

ISBN-13: 9781475704563

ISBN-10: 1475704585

ISBN-13: 9781475704587

This publication is the results of a world symposium held on the Institute of Virology and Immunobiology of the-University of WUrzburg, Germany, in October 1980. The reason of this symposium was once to supply a chance to check the knowledge on coronavirus constitution and copy­ tion in addition to to debate mechanisms of pathogenesis. For over a decade coronaviruses were famous as a tremendous team of viruses that are liable for quite a few ailments of scientific value in animals and guy. lately new and fascinating information at the molecular biology and pathogenesis of coronaviruses became on hand and this led us to prepare this assembly. The uniformity and variety during this virus crew was once evaluated from a molecular perspective and the replication of coronaviruses seems to be to contain elements that could be special for this virus workforce. also, not like different optimistic strand RNA viruses it turned transparent that coronaviruses easily determine chronic infections within the host, a phenomenon that can result in different subacute or continual issues manifested in the course of coronavirus an infection. This quantity offers a sequence of articles established upon the clinical presentation given on the symposium. moreover, there are articles by way of B. W. J. Mahy and D. A. J. Tyrrell which summarize the present nation of artwork about the biochemistry and biology of coronaviruses, respective­ ly. We think this booklet might be of curiosity to all virologists and especially to either tested staff and newbies to this box. V.

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2. Bradburne, AF: Antigenic relationships amongst coronaviruses. Arch. ges Virusforsch. 31:352-364, 1970. 3. Burks, JS, DeVald, BL, Jankovsky, LO, and Gerdes, JC: Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients. Science 209:933-934, 1980. 4. Cheever, FS and Mueller, JH: Epidemic diarrheal disease of suckling mice. I. Manifestations, epidemiology, and attempts to transmit the disease. Exp. Med. 85:405-416, 1947. 5. , and Burks, JS: Multiple sclerosis virus isolates SK and SD are serologically related to murine coronaviruses A59 and JHM and human coronavirus OC43, but not to human coronavirus 229E.

Procedure (2) gave a mean 5l00-fold reduction in total protein with a 96% yield. 007% of crude culture radioactivity. The criteria of purity established for OC-43 were met for 229E as well. 2 nm. D. 3 at cm 256 nm. All values were corrected for light scattering. Gel electrophoresis was carried out in continuous phosphate gels as used for OC-43 30 and in discontinuous Tris-glycine gels. 40 Gels were stained for protein, phosphoprotein, glycoprotein, and lipoprotein and scanned as before. 30 Seven polypeptides were consistently found, six of which appeared to contain carbohydrate and one lipid (Table 1).

RNAs in each mixture, after preparation, were precipitated with ethanol in the presence of carrier RNA and analyzed in sucrose gradients. The profiles of acid-insoluble radioactivity for each gradient showed the same heterogeneity for the major class of OC-43 RNA fragments already noted by the phenol extraction method (Figs. 3,4) and 56 J. C. HIERHOLZER ET AL. again confirm the presence of a minor 4S component. Both TMV RNA and 70S RSV RNA remained undegraded after extraction, suggesting that the heterogeneity of the major RNA class is caused not by the activation of ribonucleases but by disruption of noncovalent linkages between RNA fragments which are much weaker than similar linkages within the 70S RSV RNA.

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Biochemistry and Biology of Coronaviruses by Lawrence S. Sturman (auth.), V. ter Meulen, S. Siddell, H. Wege (eds.)

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