Download e-book for kindle: Airway Smooth Muscle in Asthma and COPD: Biology and by Kian Fan Chung

By Kian Fan Chung

ISBN-10: 0470060662

ISBN-13: 9780470060667

During this e-book, major researchers in medication and molecular pharmacology clarify the mobile mechanisms that keep an eye on airway soft muscle. The ability wherein those are disrupted in illness, and the pharmacologic ideas through which they're changed are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity presents the clinician with the hottest details on one of many center physiological procedures in airway ailment, and provides insights into present and destiny ways to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates most up-to-date learn to bronchodilator therapyMulti-contributed textual content, co-coordinated through of the prime specialists within the box.

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Et al. (2006). The role of F-actin and myosin in epithelial cell rheology. Biophys J 91, 3946–3956. Wang, C. , Almirall, J. , Dolman, C. S. et al. (1997). In vitro bronchial responsiveness in two highly inbred rat strains. J Appl Physiol 82, 1445–1452. , McParland, B. E. and Par´e, P. D. (2003). The functional consequences of structural changes in the airways: implications for airway hyperresponsiveness in asthma. Chest 123, 356S–362S. , Par´e, P. D. and Seow, C. Y. (2001). Effect of chronic passive length change on airway smooth muscle length–tension relationship.

1998). , 1998). , 2006). , 2004). The idea of functional differentiation among different actin isoforms was strengthened by studies of smooth muscle cytoskeletal organization by Small and colleagues, who observed distinct subsets of actin filaments localized to different physical domains within the smooth muscle cell (Small, 1995). They reported ‘cytoskeletal’ ␤-actin to be selectively localized to the cytoplasmic dense bodies, the membrane adhesion sites, and the longitudinal channels linking consecutive dense bodies, which are also occupied by filamin and desmin.

Et al. (1992). Ragweed sensitization-induced increase of myosin light chain kinase content in canine airway smooth muscle. Am J Respir Cell Mol Biol 7, 567–573. Johnson, P. , Tamm, M. et al. (2001). Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 164, 474–477. Kelleher, M. , Abe, M. , Chao, T. S. et al. (1995). Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis. Am J Physiol 268, L894–L901. Kubo, R. (1986). Brownian motion and nonequilibrium statistical mechanics.

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Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology by Kian Fan Chung


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