Download e-book for kindle: ABC Transporters and Multidrug Resistance by Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

By Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

A finished evaluate of the most up-tp-date clinical examine on ABC transporters and multidrug resistance

ATP-binding cassette transporter genes (ABC transporters) are identified to play an important function within the improvement of multidrug resistance (MDR). MDR is the facility of pathologic cells, akin to tumors, to resist chemical compounds designed to focus on and smash such cells. In MDR, sufferers who're on drugs ultimately advance resistance not to purely the drug they're taking, yet to a number of sorts of drugs.

ABC Transporters and Multidrug Resistance deals an important source for pharmaceutical researchers who're operating to find medications to counteract multidrug resistance in illnesses similar to melanoma. in a single entire quantity, this ebook encompasses a number of the most up-tp-date wisdom at the involvement of ABC transporters in drug delivery and resistance.

This accomplished quantity presents an summary at the description of the constitution, the genome, basic tissue expression, physiological element, and mechanism of motion of the ABC protein. The specialist members discover the expression, detection, and implications of ABC proteins in hematological malignancies and good tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. additionally, the e-book bargains crucial info at the organic and scientific element of multidrug resistance.

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Extra resources for ABC Transporters and Multidrug Resistance

Example text

Multiple molecular mechanisms for multidrug resistance transporters. Nature 446: 749–757. 6. Juliano RL and Ling V. 1976. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455: 152–162. 7. Gottesman MM and Ling V. 2006. The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research. FEBS Lett 580: 998–1009. 8. Loo TW and Clarke DM. 2005. Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

Int J Oncol 22: 1117–1121. 51. Vaclavikova R, Nordgard SH, Alnaes GI, Hubackova M, Kubala E, Kodet R et al. 2008. Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): Effects on its expression and clinicopathological characteristics in breast cancer patients. Pharmacogenet Genomics 18: 263–273. 52. Sam SS, Thomas V, Sivagnanam K, Reddy KS, Surianarayanan G, and Chandrasekaran A. 2007. ABCB1 genetic polymorphism and risk of upper aerodigestive tract cancers among smokers, tobacco chewers and alcoholics in an Indian population.

PART I ABC PROTEINS: AN OVERVIEW AND DESCRIPTION OF THE STRUCTURE, GENOME, NORMAL TISSUE EXPRESSION, PHYSIOLOGICAL ASPECT, AND MECHANISM OF ACTION 1 THE P-GLYCOPROTEIN 170: JUST A MULTIDRUG RESISTANCE PROTEIN OR A PROTEAN MOLECULE? 1. 2. 1. 2. 3. 4. 3. 1. 2. 4. 1. 2. 3. 4. 5. Conclusion References 18 18 18 22 23 25 27 27 29 30 30 33 33 34 35 35 ABC Transporters and Multidrug Resistance, Edited by Ahcène Boumendjel, Jean Boutonnat and Jacques Robert Copyright © 2009 by John Wiley & Sons, Inc. 1.

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ABC Transporters and Multidrug Resistance by Ahcène Boumendjel, Jean Boutonnat, Jacques Robert


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